Mesothelioma diagnosis is very important as far as an early treatment is considered. It helps with better pain management. Mesothelioma diagnosis is confusing as the symptoms mimic many lung infections.
Steps
1. Don't sit there and keep guessing. Consult your physician.
2. Get Mesothelioma tests done. An early initiation of treatment will help reduce the cancer pain considerably.
* Valuable Imaging techniques used in Mesothelioma tests are X Ray, CT (Computerized tomography), MRI (Magnetic Resonance Imaging) and PET (Positive Electron Tomography)
* Invasive procedures for Tissue and fluid samples are also done. Usually invasive procedures {which invade the body} are required to make a final confirmed Mesothelioma Diagnosis (Thoracoscopy, Peritoneoscopy and Biopsy)
* Recently the first ever Blood test for Mesothelioma have been devised as reported by Pacific North-West Research Institute. This is basedon the fact that [ cells release tumor markers called SMR (Soluble mesothelin-related) proteins
3. Two important questions you should answer before you go ahead with the Mesothelioma diagnosis are: Have you been exposed to asbestos? (Although not all the Mesothelioma cases are direct results of asbestos exposure there is a strong association between the two.) Do you experience Mesothelioma symptoms?
1. Don't sit there and keep guessing. Consult your physician.
2. Get Mesothelioma tests done. An early initiation of treatment will help reduce the cancer pain considerably.
* Valuable Imaging techniques used in Mesothelioma tests are X Ray, CT (Computerized tomography), MRI (Magnetic Resonance Imaging) and PET (Positive Electron Tomography)
* Invasive procedures for Tissue and fluid samples are also done. Usually invasive procedures {which invade the body} are required to make a final confirmed Mesothelioma Diagnosis (Thoracoscopy, Peritoneoscopy and Biopsy)
* Recently the first ever Blood test for Mesothelioma have been devised as reported by Pacific North-West Research Institute. This is basedon the fact that [ cells release tumor markers called SMR (Soluble mesothelin-related) proteins
3. Two important questions you should answer before you go ahead with the Mesothelioma diagnosis are: Have you been exposed to asbestos? (Although not all the Mesothelioma cases are direct results of asbestos exposure there is a strong association between the two.) Do you experience Mesothelioma symptoms?
Tips
* If you suspect that you have been exposed to asbestos then get mesothelioma tests done at the earliest.
Warnings
* Mis-Diagnosis and late diagnosis is a grave error in mesothelioma as the treatment becomes difficult with late diagnosis.
Source
Tuesday, November 20, 2007
Mesothelioma Diagnosis
Mesothelioma diagnosis typically begins with a sufferer's visit to the doctor complaining of chronic chest pain. This pain is caused as a result of a buildup of fluid inside the pleural space; this is called pleural effusion and is the most common presenting symptom of malignant mesothelioma.
Preliminary mesothelioma detection can be achieved through a chest imagery scan (CT scan, x-ray); however, mesothelioma is often misdiagnosed as viral pneumonia at this stage because of certain symptomatic similarities between the two. The only way to definitively verify a suspected case of malignant mesothelioma is through a biopsy.
A biopsy is a relatively minor procedure (dependent on the location of the tumor) during which a small section of suspect tissue is removed. The removed section is examined by a histopathologist, an expert in the study of diseased tissue. Histopathological examination can confirm a case of malignant mesothelioma while also typing and staging it. Understanding the type and stage can help doctors suggest the best of treatment.
Histopathological Examination
Histopathologists are focused on the microscopic study of diseased tissue. A field of pathology, histopathology is a particularly useful tool in forming an accurate diagnosis of cancer and other diseases. The first step in performing a histopathological examination is excising a section of suspect tissue from the patient in question (biopsy). In order to prevent the excised tissue from decaying, it is placed in a fixative (something that increases tissue durability), the most common of which is called formalin (formaldehyde mixed with water).
In order to be prepped for viewing under a high-powered microscope, tissue samples are bathed in a number of increasingly concentrated solutions of ethanol so as to dehydrate the tissue prior to it being dipped in a type of wax called paraffin. By undergoing this procedure, the tissue sample is transformed from a soft and moist section of tissue into a hard paraffin block. This process is called embedding and is performed for the purpose of making it possible to slice the tissue into incredibly thin sections (approximately five micrometers). The ultra-thin slices allow histopathologists to view the size and structure of individual tumor cells.
A tissue section with a thickness of five micrometers is virtually transparent, forcing histopathologists to "stain" the tissue with various types of pigments (hematoxylin and eosin are common) designed to make it viewable under the microscope. Once a section of tissue has been embedded and stained, it is ready for examination.
Mesothelioma Cellular Types
Histopathological examination provides a definitive mesothelioma diagnosis in addition to providing detailed information about the type of mesothelioma (pleural, peritoneal or pericardial) such as its cellular makeup. Mesothelioma cancer cells can be found in three distinct types: epithelioid, sarcomatoid and biphasic.
Epithelioid mesothelioma is the most common type of mesothelioma cancer cell, accounting for 50% to 70% of all mesothelioma cancer cells. Epithelioid cancer cells are distinguished by their unique cellular pattern. They are relatively uniform in shape with a tubular pattern and a clearly defined cell nucleus under magnification.
Sarcomatoid mesothelioma is the least common type of mesothelioma cancer cell, accounting for 10% to 15% of all mesothelioma cancer cells. Sarcomatoid cancer cells are typically oval shaped, but more irregular with a less visible cell nucleus under magnification.
Biphasic mesothelioma is the second most common type of mesothelioma cancer cell, accounting for 25% to 60% of all mesothelioma cancer cells. Biphasic cancer cells do not have a unique pattern because they are a combination of epithelioid cells and sarcomatoid cells. Biphasic mesothelioma cancer cells can be intertwined or isolated from one another across the tumor mass. The latter configuration can lead to a misdiagnosis of cellular type if an excised section of tissue contains only epithelioid or sarcomatoid cells.
Source
Preliminary mesothelioma detection can be achieved through a chest imagery scan (CT scan, x-ray); however, mesothelioma is often misdiagnosed as viral pneumonia at this stage because of certain symptomatic similarities between the two. The only way to definitively verify a suspected case of malignant mesothelioma is through a biopsy.
A biopsy is a relatively minor procedure (dependent on the location of the tumor) during which a small section of suspect tissue is removed. The removed section is examined by a histopathologist, an expert in the study of diseased tissue. Histopathological examination can confirm a case of malignant mesothelioma while also typing and staging it. Understanding the type and stage can help doctors suggest the best of treatment.
Histopathological Examination
Histopathologists are focused on the microscopic study of diseased tissue. A field of pathology, histopathology is a particularly useful tool in forming an accurate diagnosis of cancer and other diseases. The first step in performing a histopathological examination is excising a section of suspect tissue from the patient in question (biopsy). In order to prevent the excised tissue from decaying, it is placed in a fixative (something that increases tissue durability), the most common of which is called formalin (formaldehyde mixed with water).
In order to be prepped for viewing under a high-powered microscope, tissue samples are bathed in a number of increasingly concentrated solutions of ethanol so as to dehydrate the tissue prior to it being dipped in a type of wax called paraffin. By undergoing this procedure, the tissue sample is transformed from a soft and moist section of tissue into a hard paraffin block. This process is called embedding and is performed for the purpose of making it possible to slice the tissue into incredibly thin sections (approximately five micrometers). The ultra-thin slices allow histopathologists to view the size and structure of individual tumor cells.
A tissue section with a thickness of five micrometers is virtually transparent, forcing histopathologists to "stain" the tissue with various types of pigments (hematoxylin and eosin are common) designed to make it viewable under the microscope. Once a section of tissue has been embedded and stained, it is ready for examination.
Mesothelioma Cellular Types
Histopathological examination provides a definitive mesothelioma diagnosis in addition to providing detailed information about the type of mesothelioma (pleural, peritoneal or pericardial) such as its cellular makeup. Mesothelioma cancer cells can be found in three distinct types: epithelioid, sarcomatoid and biphasic.
Epithelioid mesothelioma is the most common type of mesothelioma cancer cell, accounting for 50% to 70% of all mesothelioma cancer cells. Epithelioid cancer cells are distinguished by their unique cellular pattern. They are relatively uniform in shape with a tubular pattern and a clearly defined cell nucleus under magnification.
Sarcomatoid mesothelioma is the least common type of mesothelioma cancer cell, accounting for 10% to 15% of all mesothelioma cancer cells. Sarcomatoid cancer cells are typically oval shaped, but more irregular with a less visible cell nucleus under magnification.
Biphasic mesothelioma is the second most common type of mesothelioma cancer cell, accounting for 25% to 60% of all mesothelioma cancer cells. Biphasic cancer cells do not have a unique pattern because they are a combination of epithelioid cells and sarcomatoid cells. Biphasic mesothelioma cancer cells can be intertwined or isolated from one another across the tumor mass. The latter configuration can lead to a misdiagnosis of cellular type if an excised section of tissue contains only epithelioid or sarcomatoid cells.
Source
Mesothelioma Alternative Cancer Treatment
The clinic has treated many peritoneal mesotheliotics who have achieved "remarkable" results.
# A 64 year old gentleman from Buffalo, New York was diagnosed with pleural malignant mesothelioma in early 1998. He underwent the extra-pleural pneumonectomy by Dr. Sugarbaker, followed by three (3) chemotherapy and fifteen (15) radiation treatments in July of 1998. In September, doctors discovered the mesothelioma had spread to his healthy lung. He was given two (2) months to live. He learned of the IAT clinic from his neighbor and traveled to the Bahamas in December. "I should be dead! But here I am! I feel good and I plan on feeling good for a long time."
# A 77 year old gentleman, also from Buffalo, was diagnosed with pleural malignant mesothelioma in September of 1997. He was offered no treatment and given radiation only to the biopsy wound. His family researched the Internet and local libraries in search of alternative treatments. They discovered the IAT clinic while reading about alternative therapies in a book. He traveled to the Bahamas in September of 1998. "I had to quit working because of the mesothelioma. All my life I got up in the morning and went to work." After going to the IAT clinic, he no longer gets tired "just sitting around." He is able to walk his dog, pull weeds in his yard and, as he puts it -- he has been blessed with the privilege of living.
# Cori Harth was first diagnosed with malignant mesothelioma in 1997 at the age of 49. She is continuing to live a strong and active life. "Having been told I probably would not make it to my 50th birthday, and having celebrated my 51st in the Bahamas doing fantastic, I have ample reason to be very thankful. The mesothelioma is no doubt still "there", but between the laetrile and IAT and stem cell, plus continuing my usual juicing, vitamins and minerals, regular exercise, as well as a good attitude, faith and prayer, my immune system is giving the tumor one heck of a run for its money!!!! All I can say is that it is not anecdotal - they treat many different types of cancers there, and believe me, all you would have to do is spend some hours in the clinic talking to patients from all walks of life. And Dr. Clement is totally open to having anyone talk to the patients, and most patients are happy to do so."
# Two men, ages 45 and 38 respectively, who suffered from peritoneal mesothelioma. Both were diagnosed in 1980. The 45 year old underwent conventional chemotherapy (cytoxan, adriamyein, etc.) prior to arriving at the IAT Clinic. The 38 year old had several of the tumors surgically removed. Both started receiving sera treatment in 1980. As of 1988, both reportedly "were in good health." The brochure is undated.
# A 79 year old liver cancer patient from Minnesota who was diagnosed over one year ago. He joked: "I look pretty good for being dead. My doctors gave me six weeks to live. I've been to more places and seen more things than most people, but I was not ready to give up." This patient learned of the clinic from a friend of his ex-wife.
# A 50 year old breast cancer patient from the East Coast. She was diagnosed two years ago. Her doctors gave her no hope for a cure. She learned of the IAT clinic through her veterinarian. We met a 65 year old prostate cancer patient from Colorado who diagnosed in 1990. His urologist told him of the clinic. He is doing very well.
# An 80 year old breast cancer patient from New York. She was diagnosed five years ago and underwent several chemotherapy treatments. Her doctors told her she was to begin radiation treatments as soon as she "got her health back." She did not wait and traveled to the clinic. Now, she is "too busy with my life to find time to play golf, which I love!"
# A 50 year old breast cancer patient from Huntsville, Alabama. She was first diagnosed in 1981 and was told of the clinic by a friend who was being treated for brain cancer. She stopped taking the treatments in 1991. In 1994, she was diagnosed with liver cancer and offered the same conventional treatment as was offered by her doctors in 1981. She went back to the clinic and resumed taking the sera. Today, she is active and leading a "normal" life.
# A 60 year old leukemia patient from New York. She was diagnosed in the early 1970's. In fact, she was the third patient ever treated with the sera by Dr. Burton.
# A doctor from Scotland who is in complete remission after being diagnosed fifteen (15) years ago. A doctor from St. Louis, Missouri was diagnosed with colon cancer eight (8) years ago, a doctor from Seattle, Washington diagnosed with prostate cancer nine (9) years ago. Each was advised by their personal doctors that their tumors were beyond the reach of conventional medicine.
Nowak AK, Lake RA, Kindler HL, Robinson BW. New approaches for mesothelioma: biologics, vaccines, gene therapy, and other novel agents. Semin Oncol. 2002 Feb;29(1):82-96.
University Department of Medicine, University of Western Australia, Verdun St Nedlands, Australia.
Although malignant mesothelioma is not a classically immunogenic cancer, there is abundant evidence for immune recognition. The relative ease of obtaining tumor tissue makes mesothelioma ideal for studying surrogate biomarkers such as lymphocytic infiltration or expression of transduced genes. There is evidence that malignant mesothelioma patients as well as asbestos-exposed persons without mesothelioma have impaired immune responsiveness. Substantial progress has been made in animal models using several biological and immunological techniques, but clinical application has been problematic. Systems studied have included lysis by interleukin-2 (IL-2)-activated lymphokine-activated killer (LAK) cells, tumor necrosis factor-alpha (TNF-alpha), a p16-expressing adenovirus vector, suicide gene therapy using the herpes simplex virus-tyrosine kinase (HSV-tk) followed by ganciclovir, and immunomodulatory gene therapy with IL-2, IL-4, interferon-gamma (IFN-gamma), IFN-alpha, TNF-alpha, granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-6, and IL-1beta transfected into tumors. Vaccinia virus has been studied as a vector for cytokine gene transfer. Suicide gene therapy has been combined with a tumor vaccine. The University of Western Australia is initiating a pilot study of autologous vaccination in malignant mesothelioma. Novel agents under study include the angiogenesis inhibitors SU5416, bevacizumab, and thalidomide. ZD1839, an orally administered, highly selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase, is being tested in a phase II trial. Since platelet-derived growth factor (PDGF) is thought to be an autocrine growth factor for mesothelioma STI-571 (Gleevec; Novartis, Basel, Switzerland), a highly selective inhibitor of the PDGF receptor tyrosine kinase, is being tested in a phase II trial. The development of more active cytotoxic combinations in this disease should facilitate further studies of chemoimmunotherapy. It seems likely that no single treatment modality will be effective by itself. Copyright 2002 by W.B. Saunders Company.
Eradication of intraperitoneal and distant tumor by adenovirus-mediated interferon-beta gene therapy is attributable to induction of systemic immunity. Cancer Res. 2001 Aug 15;61(16):6201-12.
Odaka M, Sterman DH, Wiewrodt R, Zhang Y, Kiefer M, Amin KM, Gao GP, Wilson JM, Barsoum J, Kaiser LR, Albelda SM. Thoracic Oncology Research Laboratory, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA.
Malignant mesothelioma remains an incurable disease for which immune-modulatory therapies, such as exogenous cytokines, have shown some promise. One such cytokine, IFN-beta, has potent antiproliferative and immunostimulatory activity in vitro, but its in vivo use has been limited by toxicity. We thus conducted studies evaluating intracavitary delivery of a replication-deficient adenoviral (Ad) vector encoding for the murine IFN-beta gene (Ad.muIFN-beta) in mouse models of malignant mesothelioma. In contrast to multiple injections of recombinant protein, a single i.p. injection of Ad.muIFN-beta into animals with established tumors elicited remarkable antitumor activity leading to long-term survival in >90% of animals bearing either AB12 or AC29 i.p. mesotheliomas. A control adenovirus vector had minimal antitumor effect in vivo. Significant therapeutic effects were also seen in animals treated with large tumor burdens. Importantly, treatment of i.p. tumor also led to reduction of growth in tumors established at a distant site (flank). A number of experiments suggested that these effects were attributable to an acquired CD8(+) T-cell-mediated response including: (a) the induction of long-lasting antitumor immunity; (b) loss of efficacy of Ad.muIFN-beta in tumor-bearing, immune-deficient (SCID, SCID/beige) mice; (c) detection of high levels of specific antitumor cytolytic activity from unstimulated splenocytes harvested from Ad.muIFN-beta-treated animals that was abolished by CD8(+) T-cell depletion; and (d) abrogation of antitumor effects of Ad.muIFN-beta in tumor-bearing CD8(+) T-cell-depleted animals. These data show that intracavitary IFN-beta gene therapy using an adenoviral vector provides strong CD8(+) T-cell-mediated antitumor effects in murine models of mesothelioma and suggest that this may be a promising strategy for the treatment of localized tumors such as mesothelioma or ovarian cancer in humans.
Source
# A 64 year old gentleman from Buffalo, New York was diagnosed with pleural malignant mesothelioma in early 1998. He underwent the extra-pleural pneumonectomy by Dr. Sugarbaker, followed by three (3) chemotherapy and fifteen (15) radiation treatments in July of 1998. In September, doctors discovered the mesothelioma had spread to his healthy lung. He was given two (2) months to live. He learned of the IAT clinic from his neighbor and traveled to the Bahamas in December. "I should be dead! But here I am! I feel good and I plan on feeling good for a long time."
# A 77 year old gentleman, also from Buffalo, was diagnosed with pleural malignant mesothelioma in September of 1997. He was offered no treatment and given radiation only to the biopsy wound. His family researched the Internet and local libraries in search of alternative treatments. They discovered the IAT clinic while reading about alternative therapies in a book. He traveled to the Bahamas in September of 1998. "I had to quit working because of the mesothelioma. All my life I got up in the morning and went to work." After going to the IAT clinic, he no longer gets tired "just sitting around." He is able to walk his dog, pull weeds in his yard and, as he puts it -- he has been blessed with the privilege of living.
# Cori Harth was first diagnosed with malignant mesothelioma in 1997 at the age of 49. She is continuing to live a strong and active life. "Having been told I probably would not make it to my 50th birthday, and having celebrated my 51st in the Bahamas doing fantastic, I have ample reason to be very thankful. The mesothelioma is no doubt still "there", but between the laetrile and IAT and stem cell, plus continuing my usual juicing, vitamins and minerals, regular exercise, as well as a good attitude, faith and prayer, my immune system is giving the tumor one heck of a run for its money!!!! All I can say is that it is not anecdotal - they treat many different types of cancers there, and believe me, all you would have to do is spend some hours in the clinic talking to patients from all walks of life. And Dr. Clement is totally open to having anyone talk to the patients, and most patients are happy to do so."
# Two men, ages 45 and 38 respectively, who suffered from peritoneal mesothelioma. Both were diagnosed in 1980. The 45 year old underwent conventional chemotherapy (cytoxan, adriamyein, etc.) prior to arriving at the IAT Clinic. The 38 year old had several of the tumors surgically removed. Both started receiving sera treatment in 1980. As of 1988, both reportedly "were in good health." The brochure is undated.
# A 79 year old liver cancer patient from Minnesota who was diagnosed over one year ago. He joked: "I look pretty good for being dead. My doctors gave me six weeks to live. I've been to more places and seen more things than most people, but I was not ready to give up." This patient learned of the clinic from a friend of his ex-wife.
# A 50 year old breast cancer patient from the East Coast. She was diagnosed two years ago. Her doctors gave her no hope for a cure. She learned of the IAT clinic through her veterinarian. We met a 65 year old prostate cancer patient from Colorado who diagnosed in 1990. His urologist told him of the clinic. He is doing very well.
# An 80 year old breast cancer patient from New York. She was diagnosed five years ago and underwent several chemotherapy treatments. Her doctors told her she was to begin radiation treatments as soon as she "got her health back." She did not wait and traveled to the clinic. Now, she is "too busy with my life to find time to play golf, which I love!"
# A 50 year old breast cancer patient from Huntsville, Alabama. She was first diagnosed in 1981 and was told of the clinic by a friend who was being treated for brain cancer. She stopped taking the treatments in 1991. In 1994, she was diagnosed with liver cancer and offered the same conventional treatment as was offered by her doctors in 1981. She went back to the clinic and resumed taking the sera. Today, she is active and leading a "normal" life.
# A 60 year old leukemia patient from New York. She was diagnosed in the early 1970's. In fact, she was the third patient ever treated with the sera by Dr. Burton.
# A doctor from Scotland who is in complete remission after being diagnosed fifteen (15) years ago. A doctor from St. Louis, Missouri was diagnosed with colon cancer eight (8) years ago, a doctor from Seattle, Washington diagnosed with prostate cancer nine (9) years ago. Each was advised by their personal doctors that their tumors were beyond the reach of conventional medicine.
Nowak AK, Lake RA, Kindler HL, Robinson BW. New approaches for mesothelioma: biologics, vaccines, gene therapy, and other novel agents. Semin Oncol. 2002 Feb;29(1):82-96.
University Department of Medicine, University of Western Australia, Verdun St Nedlands, Australia.
Although malignant mesothelioma is not a classically immunogenic cancer, there is abundant evidence for immune recognition. The relative ease of obtaining tumor tissue makes mesothelioma ideal for studying surrogate biomarkers such as lymphocytic infiltration or expression of transduced genes. There is evidence that malignant mesothelioma patients as well as asbestos-exposed persons without mesothelioma have impaired immune responsiveness. Substantial progress has been made in animal models using several biological and immunological techniques, but clinical application has been problematic. Systems studied have included lysis by interleukin-2 (IL-2)-activated lymphokine-activated killer (LAK) cells, tumor necrosis factor-alpha (TNF-alpha), a p16-expressing adenovirus vector, suicide gene therapy using the herpes simplex virus-tyrosine kinase (HSV-tk) followed by ganciclovir, and immunomodulatory gene therapy with IL-2, IL-4, interferon-gamma (IFN-gamma), IFN-alpha, TNF-alpha, granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-6, and IL-1beta transfected into tumors. Vaccinia virus has been studied as a vector for cytokine gene transfer. Suicide gene therapy has been combined with a tumor vaccine. The University of Western Australia is initiating a pilot study of autologous vaccination in malignant mesothelioma. Novel agents under study include the angiogenesis inhibitors SU5416, bevacizumab, and thalidomide. ZD1839, an orally administered, highly selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase, is being tested in a phase II trial. Since platelet-derived growth factor (PDGF) is thought to be an autocrine growth factor for mesothelioma STI-571 (Gleevec; Novartis, Basel, Switzerland), a highly selective inhibitor of the PDGF receptor tyrosine kinase, is being tested in a phase II trial. The development of more active cytotoxic combinations in this disease should facilitate further studies of chemoimmunotherapy. It seems likely that no single treatment modality will be effective by itself. Copyright 2002 by W.B. Saunders Company.
Eradication of intraperitoneal and distant tumor by adenovirus-mediated interferon-beta gene therapy is attributable to induction of systemic immunity. Cancer Res. 2001 Aug 15;61(16):6201-12.
Odaka M, Sterman DH, Wiewrodt R, Zhang Y, Kiefer M, Amin KM, Gao GP, Wilson JM, Barsoum J, Kaiser LR, Albelda SM. Thoracic Oncology Research Laboratory, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA.
Malignant mesothelioma remains an incurable disease for which immune-modulatory therapies, such as exogenous cytokines, have shown some promise. One such cytokine, IFN-beta, has potent antiproliferative and immunostimulatory activity in vitro, but its in vivo use has been limited by toxicity. We thus conducted studies evaluating intracavitary delivery of a replication-deficient adenoviral (Ad) vector encoding for the murine IFN-beta gene (Ad.muIFN-beta) in mouse models of malignant mesothelioma. In contrast to multiple injections of recombinant protein, a single i.p. injection of Ad.muIFN-beta into animals with established tumors elicited remarkable antitumor activity leading to long-term survival in >90% of animals bearing either AB12 or AC29 i.p. mesotheliomas. A control adenovirus vector had minimal antitumor effect in vivo. Significant therapeutic effects were also seen in animals treated with large tumor burdens. Importantly, treatment of i.p. tumor also led to reduction of growth in tumors established at a distant site (flank). A number of experiments suggested that these effects were attributable to an acquired CD8(+) T-cell-mediated response including: (a) the induction of long-lasting antitumor immunity; (b) loss of efficacy of Ad.muIFN-beta in tumor-bearing, immune-deficient (SCID, SCID/beige) mice; (c) detection of high levels of specific antitumor cytolytic activity from unstimulated splenocytes harvested from Ad.muIFN-beta-treated animals that was abolished by CD8(+) T-cell depletion; and (d) abrogation of antitumor effects of Ad.muIFN-beta in tumor-bearing CD8(+) T-cell-depleted animals. These data show that intracavitary IFN-beta gene therapy using an adenoviral vector provides strong CD8(+) T-cell-mediated antitumor effects in murine models of mesothelioma and suggest that this may be a promising strategy for the treatment of localized tumors such as mesothelioma or ovarian cancer in humans.
Source
Thursday, November 15, 2007
Pinay Scandal Revealed!
Today I am revealing some "Pinay Scandal" - no it's not about me and my adventures/mis-adventures, ohh gosh I got too much scandals already here in my blog.
What Am talking about is "Pinay Scandal" by Marhgil Macuha. Originally it is an SEO contest. I didn’t think it would catch fire until macuha.com according to Pinoy Ambisyoso, many posted comments on his Pinay Scandal post, and are interested to join this campaign. Get started now - this was simply similar to the Viral Tags that went around and got me right at the bottom - before I knew it, my ratings on Technorati and Alexa has jumped 10-fold! This campaign will generate tons of traffic from Pinoys searching for a piece of something.. and guess what? We just changed the Google Trend for this keyword. They’ll find your blog instead!! Haha!
I will make serial updates to this post adding those that will join the campaign. Let’s continue the experiment and see where it takes us… Goodluck bloggers! Let us change the
The Pinay Scandal Hitlist posted below.
1. Wanna know the latest trend about Pinay Scandal? by Dexter of Tech At Hand
2. Pinay Scandal… The Issue by Darang Sisa
3. Pinay Scandal by Almer Viloria
4. Google Suggested Pinay Scandal by Ada
5. Pinay Scandal by Ada
6. Pinay Scandal by Catzie
7. Pinay Scandal by Jehzeel Laurente
8. Pinay Scandals: Earning Big Bucks? by Nika
9. Pinay Scandal by Heart
10. Looking For Pinay Scandals?! by Eli
11. Pinay Scandal by Eligio
12. Pinay Scandal by Stentorized
13. Pinay Scandal by Caryl
14. Pinay Scandal o Iskandalosang Pinay by Kengkay
15. Pinay Scandal by Hazel
16. Pinay Scandal by Baby Face
17. Pinay Scandal Story by Pinoy Ambisyoso
18. Pinay Scandal by Kenneth
19. Pinay Scandal by JoanJoyce
20. Pinay Scandal, Anyone? by MyGlitch
21. Pinay Scandal Here by Jojitah
22. “Pinay Scandal” Idea by Neil
23. Pinay Scandal… In The Mind Of Pinays by Marikenya
24. The Pinay Scandal - Most Outrageous and Raw Scandal by Chuva
25. Pinoy Scandal Survivor No. 1 Proud Filipina: Julie Borje by Marikenya
26. Pinay Scandal by Chuvaness
27. The Best of Pinay Scandals by Rhodilee
28. Pinay Scandal by Che
29. Pinay Scandal by JeanGrey
30. Pinay Scandal Revealed! by Glitchline
31. Pinay Scandal on the Web by Philippine Elections 2007
32. Pinay Scandal, Let’s Play The Trend by Selaplana
33. The Hottest Pinay Scandals by iRonnie
34. Blog About Filipina, Pinay Scandal And Vedio by Allen
35. Pinay Scandal Video by Ronald Mojica
36. Pinay Scandal by Paulyn
37. Pinay Scandal Videos by Mi
38. Pinay Scandals by RhyannefranzWhat Am talking about is "Pinay Scandal" by Marhgil Macuha. Originally it is an SEO contest. I didn’t think it would catch fire until macuha.com according to Pinoy Ambisyoso, many posted comments on his Pinay Scandal post, and are interested to join this campaign. Get started now - this was simply similar to the Viral Tags that went around and got me right at the bottom - before I knew it, my ratings on Technorati and Alexa has jumped 10-fold! This campaign will generate tons of traffic from Pinoys searching for a piece of something.. and guess what? We just changed the Google Trend for this keyword. They’ll find your blog instead!! Haha!
I will make serial updates to this post adding those that will join the campaign. Let’s continue the experiment and see where it takes us… Goodluck bloggers! Let us change the
The Pinay Scandal Hitlist posted below.
1. Wanna know the latest trend about Pinay Scandal? by Dexter of Tech At Hand
2. Pinay Scandal… The Issue by Darang Sisa
3. Pinay Scandal by Almer Viloria
4. Google Suggested Pinay Scandal by Ada
5. Pinay Scandal by Ada
6. Pinay Scandal by Catzie
7. Pinay Scandal by Jehzeel Laurente
8. Pinay Scandals: Earning Big Bucks? by Nika
9. Pinay Scandal by Heart
10. Looking For Pinay Scandals?! by Eli
11. Pinay Scandal by Eligio
12. Pinay Scandal by Stentorized
13. Pinay Scandal by Caryl
14. Pinay Scandal o Iskandalosang Pinay by Kengkay
15. Pinay Scandal by Hazel
16. Pinay Scandal by Baby Face
17. Pinay Scandal Story by Pinoy Ambisyoso
18. Pinay Scandal by Kenneth
19. Pinay Scandal by JoanJoyce
20. Pinay Scandal, Anyone? by MyGlitch
21. Pinay Scandal Here by Jojitah
22. “Pinay Scandal” Idea by Neil
23. Pinay Scandal… In The Mind Of Pinays by Marikenya
24. The Pinay Scandal - Most Outrageous and Raw Scandal by Chuva
25. Pinoy Scandal Survivor No. 1 Proud Filipina: Julie Borje by Marikenya
26. Pinay Scandal by Chuvaness
27. The Best of Pinay Scandals by Rhodilee
28. Pinay Scandal by Che
29. Pinay Scandal by JeanGrey
30. Pinay Scandal Revealed! by Glitchline
31. Pinay Scandal on the Web by Philippine Elections 2007
32. Pinay Scandal, Let’s Play The Trend by Selaplana
33. The Hottest Pinay Scandals by iRonnie
34. Blog About Filipina, Pinay Scandal And Vedio by Allen
35. Pinay Scandal Video by Ronald Mojica
36. Pinay Scandal by Paulyn
37. Pinay Scandal Videos by Mi
39. Pinay Scandal Revealed! by Mesothelioma Info
40. Pinay Scandal or Pinay Sex Scandal SEO Project by Lestat
41. Pinay Scandal Here by Ronald
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Tuesday, November 13, 2007
Saturday, November 10, 2007
Mesothelioma Survivors: John Smith, Age 64
I was always taught by my parents that to live a successful life, I should be an honest, hard-working and compassionate person.I lived each and every day of my life like this.
I began working in the manufacturing plant of a large auto company once I was finished with school. I married my wife 40 years ago and always provided for her and my four kids. We lived a good life, were never wealthy, but comfortable and happy.
I worked long hours, 10 to 12 hours a day, 5 to 6 days a week, so that my wife could stay at home and raise our children. I was an honest man who worked his way up to plant manager. I was fair to my workers, and worked side-by-side with them in each area of the plant. We were dedicated to our company and gave them the best years of our lives.
And we were happy to do it.
Now, decades later, I am being re-paid in a way I never expected…
It was almost six weeks ago now that I found out I have a very deadly form of cancer called mesothelioma. This has become the worst word in the English language to me and my family. We were devastated to hear the cruel diagnosis after a short period of time when I was having some trouble breathing. It never crossed our minds that I was breathing in deadly asbestos fibers at the workplace where I gave so much of my life, 50 hours or more a week for years.
Each breath I took while at work was contributing to my early death sentence.
I felt so betrayed.
So, I have now begun my dreaded journey to treat a disease that is said to be incurable. I have already had a pneumonectomy, which consisted of an operation to remove the lung that was infected. The recovery has been tough, but with the support of my family, I am getting through it.
The other treatments that I am facing are radiation and chemotherapy. I know that the side effects of these are said to be most unpleasant, but at this point, there really aren’t too many options. I continue to hope for a miracle and try not to let bitterness and anger fester over how this disease began in my body.
I find myself thinking of which day of work it was that I finally took in one too many deadly breaths that pushed my body into a deadly spiral towards this horrible disease. I try to fight these feelings, but sometime I just can’t help the thought of what was done to my body in the quest for profits and a better life for others.
I feel so betrayed. But, at least I am alive… That is more than can be said for many others in my position. I have the love and support of my caring wife and family, and the help of friends and associates. Each day is a struggle, but we are getting on.
And we will; until the very end.
I began working in the manufacturing plant of a large auto company once I was finished with school. I married my wife 40 years ago and always provided for her and my four kids. We lived a good life, were never wealthy, but comfortable and happy.
I worked long hours, 10 to 12 hours a day, 5 to 6 days a week, so that my wife could stay at home and raise our children. I was an honest man who worked his way up to plant manager. I was fair to my workers, and worked side-by-side with them in each area of the plant. We were dedicated to our company and gave them the best years of our lives.
And we were happy to do it.
Now, decades later, I am being re-paid in a way I never expected…
It was almost six weeks ago now that I found out I have a very deadly form of cancer called mesothelioma. This has become the worst word in the English language to me and my family. We were devastated to hear the cruel diagnosis after a short period of time when I was having some trouble breathing. It never crossed our minds that I was breathing in deadly asbestos fibers at the workplace where I gave so much of my life, 50 hours or more a week for years.
Each breath I took while at work was contributing to my early death sentence.
I felt so betrayed.
So, I have now begun my dreaded journey to treat a disease that is said to be incurable. I have already had a pneumonectomy, which consisted of an operation to remove the lung that was infected. The recovery has been tough, but with the support of my family, I am getting through it.
The other treatments that I am facing are radiation and chemotherapy. I know that the side effects of these are said to be most unpleasant, but at this point, there really aren’t too many options. I continue to hope for a miracle and try not to let bitterness and anger fester over how this disease began in my body.
I find myself thinking of which day of work it was that I finally took in one too many deadly breaths that pushed my body into a deadly spiral towards this horrible disease. I try to fight these feelings, but sometime I just can’t help the thought of what was done to my body in the quest for profits and a better life for others.
I feel so betrayed. But, at least I am alive… That is more than can be said for many others in my position. I have the love and support of my caring wife and family, and the help of friends and associates. Each day is a struggle, but we are getting on.
And we will; until the very end.
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